Fruit, leaves and stems of Juniperus procera water extracts were evaluated for their antitoxoplasmic activity, compared with that of Spiramycin drug using an intraperitoneal infection by the RH strain of Toxoplasma gondii. Female mice were infected with 2x102 tachyzoites/ml and the different treatments were given orally by using a feeding needle at dose of 400 mg/kg/day. Administration of those drugs showed a noticeable effect by reducing the number of tachyzoites present in the peritoneal fluid of the experimental mice seven days after infection. The fruit of Juniperus procera as well as Spiramycin drug recorded good results with a percentage of growth inhibition for the Toxoplasma tachyzoites as 53.5% and 98.5% respectively. Leaves extract of the tested plant inhibited 50% of tachyzoites growth, while that of stems extract was 48% compared with the tachyzoites mean number in the peritoneal fluid of the control untreated mice.
|Keywords:||Juniperus Procera, Antitoxoplasmic Activity, Spiramycin, Toxoplasma Gondii, Peritoneal Fluid, Growth Inhibition|
Vice Director of Nanotechnology Center, Department of Biological Science, Science College, King Abdulaziz University, Jeddah, Jeddah, Saudi Arabia